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This enhances OCA2 expression and thereby, melanin production. The ancestral A-allele in rs12913832 allows transcription factors to modulate long-range chromatin looping that leads to contact between the OCA2 promotor and the enhancer. OCA2 expression is regulated by the intronic SNP rs12913832, which is situated in a conserved enhancer region in HERC2. Oculocutaneous albinism type 2 ( OCA2) and its neighbouring gene the HECT domain and RCC1-like domain 2 ( HERC2) are of special interest because of their strong genetic influence on human pigmentation, especially eye colour variation. Many pigmentation genes have been extensively studied to explain human eye colour variation. In total, 37 (86%) of the 43 blue-eyed rs12913832:AA and AG Norwegians could potentially be explained by these seven variants, and we suggest including them in future prediction models.

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Additionally, we confirmed the association of the missense variants rs74653330:T and rs121918166:T with blue eye colour, and observed lighter skin colour in rs74653330:T individuals. We identified five new variants, rs74409036:A, rs78544415:T, rs72714116:T, rs191109490:C and rs551217952:C, to be the most promising candidates for explaining blue eye colour in individuals with the rs12913832:AA and AG genotype.

The new candidate variants were subsequently typed in a Norwegian biobank population (total n = 519) for population specific association analysis. In this study, we carried out massively parallel sequencing of a ~500 kbp HERC2-OCA2 region in 94 rs12913832:AA and AG Norwegians (43 blue-eyed and 51 brown-eyed) to search for novel blue eye colour variants. However, in a previous study we found that 43 of 166 Norwegians with the brown eye colour genotype rs12913832:AA or AG, did not have the expected brown eye colour. The HERC2 SNP rs12913832 is currently the best-known predictor for blue and brown eye colour. This tool added Loop Supply and Drum Supply that are the multi-gigabyte infusion.The OCA2-HERC2 region is strongly associated with human pigmentation, especially eye colour.The new version comes with creative modulation device.A top-level piano has added which is Radical Piano.Three new live-sounding instrument devices are added.In addition, Reason 11 is coming with two new synthesizers, which are Grain and Europa.As well as, This tool has thousands of sounds, that not only inspired you but also the music listeners.It comes with three brands of new organic instrument collection in Reason rack.Musicians can create tracks with synths, samplers, drum machines and loops also.From different PDFs, the user can copy/ paste your pictures, drawings, tables, etc.This tool helps to check the spelling of your text in 5 languages.For making tracks you can use margins, tabs, and indents.You can search completely and change it.Reason tool works like a phrase processor.

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